Hyaluronic Acid
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  • Oluşturulma Tarihi: 2018-10-11
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Hyaluronic Acid

What is hyaluronic acid? 

"Hyaluronic acid is a glycosaminoglycan, which is polysaccharide (essentially a very large sugar!). It is naturally occurring in connective tissue throughout our bodies, with 50 percent of it being found in our skin," says Beauty by the Geeks. "It is one of the major components of our extracellular matrix (the framework in which our skin cells sit) and it also has an important role in retaining moisture, as one molecule alone can hold up to 1000 times its own weight in water." However, as Dr Bunting explains in the video above, as we age our body's natural production of hyaluronic acid slows down. It's no surprise then that beauty brands are adding hyaluronic acid into serums and creams. 

What are the skincare benefits of hyaluronic acid?

Hydrated skin is plumper, firmer and has a luminous glow, while dehydrated skin can look dull, lacklustre and more slack. The unique ability to hold so much water makes hyaluronic acid invaluable to your skin. "In a sense, hyaluronic acid acts like a sponge holding vast amounts of water in the skin, effectively plumping out the skin and by doing so it can reduce the appearance of fine lines and wrinkles, as well as improving the skin's hydration and texture of the skin," explains Beauty by the Geeks. 

What are the different ways to use hyaluronic acid on your skin?

As Dr Bunting explains, hyaluronic acid can be injected into the dermis of the skin to fill and plump, a technique more commonly known as dermal fillers. Hyaluronic acid can also be applied topically and is a key ingredient in many serums and creams. While the molecule is too large to get down into the dermis layer, there are benefits to using it on the skin's surface. "It acts as a moisturiser through its water-attracting properties. This means it draws water into the skin to keep it hydrated, supple and functioning effectively as a barrier," says Dr Bunting. "This will produce a temporary improvement in lines and wrinkles (as all moisturisers do).”

The Telegraph..

Biology
HA, also known as hyaluronan, is named for its glassy appearance (the Greek word for glass is hyalos). The presence of a sugar is denoted by “uronic acid.” HA belongs to, and is the most abundant member of, a group of compounds called glycosaminoglycans or acid mucopolysaccharides that make up the cutaneous dermal ground substance. This amorphous substance fills the extracellular spaces between collagen fibers and bundles. It is identical in chemical and molecular form in all tissues and mammals and is therefore species-nonspecific. HA has a simple chemical structure: a linear polysaccharide of repeating disaccharide units of N-acetylglucosamine and D-glucuronic acid.
The HA molecule is a long chain with intertwining coils having a polar nature that attracts water (hydrophilic). In connective tissue, HA's main biologic function is to create volume and lubricate the intracellular structures by forming a gelatinous matrix in which collagen and elastin fibers are embedded and held together in proper alignment.
A direct correlation exists between the amount of HA in dermal tissue and the content of water in the dermis, and, therefore, the elastoviscous properties of the extracellular matrix. The concentration of naturally occurring HA in the skin decreases with age, resulting in decreased elasticity and ability to hold water (hydration), which renders the dermis less voluminous and increases the tendency of the skin to form wrinkles.
Although first isolated in 1934, HA was not developed as a dermal filler until 1989, when Endre Balazs appreciated its biocompatibility and lack of immunogenicity. A dual mechanism of action accounts for the improvement of facial wrinkles: HA integrates into dermal tissue, then attracts and binds to water molecules, which sustains the augmentation. In its natural unmodified state, implanted exogenous HA is rapidly degraded by hyaluronidase and has a half-life of 12 to 24 hours. To improve its resistance to enzymatic breakdown and increase tissue viability and in situ residency, the HA molecule must be stabilized through a chemical process of cross-linking.
There are 2 broad types of cross-linked HA: (1) animal-derived and (2) non–animal-derived synthetic HA (NASHA). Each type has 3 distinct formulations.

Etiketler: HYALURONIC ACID

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